5月22日，《科学》加速发表（First Release）我校生命学院朱斌教授团队与武汉大学药学院王隆飞教授团队的合作研究成果“DNA Polymerization Activates RNA Cleavage of an RT-like Antiviral Enzyme”。该研究首次揭示了一种通过DNA合成激活RNA切割的多功能抗病毒核酸酶DRT4。与人类拥有复杂的免疫系统抵御病毒入侵类似，细.

然而，在这些已知的生命过程中，一个共同的“规则”似乎从未被打破——所有序列特异性的聚合酶，都必须依赖一条核酸（DNA 或 RNA）作为合成的模板。那么，一个更大胆的问题随之而来——生命世界中是否存在“例外”？有没有一种聚合酶，可以完全摆脱对核酸模板的依赖，直接以蛋白质为模板来合成 DNA？ 换句话说，蛋白质所蕴含的化学信息，能否直接被“翻译”回 DNA ...

Viral reverse transcriptase (RT) plays a critical role in replication (e.g., retroviruses, that reverse transcribe RNA templates into complementary DNA) and genome mutations (e.g., ...

Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older. The disease has proven difficult to develop new treatments for, and available ...

BOSTON--(BUSINESS WIRE)--ROME Therapeutics, a biotechnology company harnessing the power of the dark genome to develop breakthrough medicines for serious diseases, announced new data validating the ...

Oral presentation at ASGCT showcases breakthrough technology enabling precise in vivo genome editing in the CNS using a ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...

On the third day of the J.P. Morgan Healthcare Conference, Arbor Biotechnologies and Vertex Pharmaceuticals announced that they would be expanding into reverse transcription-based in vivo genetic ...